The Arthroscopic Surgery Unit has over 70 publications in basic research, clinical research and scientific divulgation, to contribute to the development of medicine based on evidence in the realm of treatments using plasma in injuries to the musculoskeletal system.
The end goal of the research is to improve the quality of patients’ lives and divulge experience in the medical realm so that it can be contrasted and used by other medical professionals.
Isolation of Platelet-Derived Exosomes from Human Platelet-Rich Plasma: Biochemical and Morphological Characterization
Saumell-Esnaola M, Delgado D, García Del Caño G, Beitia M, Sallés J, González-Burguera I, Sánchez P, López de Jesús M, Barrondo S, Sánchez M.
Int J Mol Sci. 2022 Mar 5;23(5):2861
Platelet-rich plasma injections induce disease-modifying effects in the treatment of osteoarthritis in animal models
Boffa A, Salerno M, Merli G, De Girolamo L, Laver L, Magalon J, Sánchez M, Tischer T, Filardo G.
Knee Surg Sports Traumatol Arthrosc. 2021
Platelet Lysate Nebulization Protocol for the Treatment of COVID-19
Beitia M, Delgado D, Sánchez P, Vallejo de la Cueva A, Cugat JR, Sánchez M.
Int J Mol Sci. 2021 Feb 12;22(4):1856.
Autologous bioscaffolds based on different concentrations of platelet rich plasma and synovial fluid as a vehicle for mesenchymal stem cells
Garate A, Sánchez P, Delgado D, Bilbao AM, Muiños-López E, Granero-Moltó F, Orive G, Prosper F, Pedraz JL, Sánchez M
J Biomed Mater Res A. 2018 Feb;106(2):377-385.
Cryopreservation of Human Mesenchymal Stem Cells in an Allogeneic Bioscaffold based on Platelet Rich Plasma and Synovial Fluid
Gurruchaga H, Saenz del Burgo L, Garate A, Delgado D, Sánchez P, Orive G, Ciriza J, Sánchez M, Pedraz JL
Sci Rep. 2017; 7: 15733
Adult Cells Combined With Platelet-Rich Plasma for Tendon Healing: Cell Source Options
Rubio-Azpeitia E, Sánchez P, Delgado D, Andia I
Orthop J Sports Med. 2017 Feb 24;5(2):2325967117690846
Modulation of Synovial Fluid-Derived Mesenchymal Stem Cells by Intra-Articular and Intraosseous Platelet Rich Plasma Administration
Muiños-López E, Delgado D, Sánchez P, Paiva B, Anitua E, Fiz N, Aizpurua B, Guadilla J, Padilla S, Granero-Moltó F, Prósper F, Sánchez M
Stem Cells Int. 2016;2016:1247950.
The Properties of 3 Different Plasma Formulations and Their Effects on Tendinopathic Cells
Rubio-Azpeitia E, Bilbao AM, Sánchez P, Delgado D, Andia I.
American Journal of Sports Medicine
Three-Dimensional Platelet-Rich Plasma Hydrogel Model to Study Early Tendon Healing
Rubio-Azpeitia E, Sánchez P, Delgado D, Andia I.
Cells Tissues Organs. 2015 Nov 13;200(6):394-404.
Ultrasound-guided plasma rich in growth factors injections and scaffolds hasten motor nerve functional recovery in an ovine model of nerve crush injury
Sánchez M, Anitua E, Delgado D, Prado R, Sánchez P, Fiz N, Guadilla J, Azofra J, Pompei O, Orive G, Ortega M, Yoshioka T, Padilla S
J Tissue Eng Regen Med. 2015
Infiltration of plasma rich in growth factors enhances in vivo angiogenesis and improves reperfusion and tissue remodeling after severe hind limb ischemia
Anitua E, Pelacho B, Prado R, Aguirre JJ, Sánchez M, Padilla S, Aranguren XL, Abizanda G, Collantes M, Hernandez M, Perez-Ruiz A, Peñuelas I, Orive G, Prosper F
J Control Release. 2015 Mar 28;202:31-9.
Plasma rich in growth factors (PRGF-Endoret) stimulates tendon and synovial fibroblasts migration and improves the biological properties of hyaluronic acid.
Anitua E, Sánchez M, De la Fuente M, Zalduendo MM, Orive G.
Knee Surg Sports Traumatol Arthrosc. 2011 Oct 11.
Plasma rich in growth factors (PRGF-Endoret) stimulates proliferation and migration of primary keratocytes and conjunctival fibroblasts and inhibits and reverts TGF-beta1-Induced myodifferentiation.
Anitua E, Sánchez M, Merayo-Lloves J, De la Fuente M, Muruzabal F, Orive G.
Invest Ophthalmol Vis Sci. 2011 Aug 1;52(9):6066-73.
Fibroblastic response to treatment with different preparations rich in growth factors.
Anitua E, Sánchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, Andía I.
Cell Prolif. 2009 Apr;42(2):162-70.
Autologous PRGF in the ovine ACL-transected knee osteoarthritis model.
Sánchez M, Anitua E, Guadilla J, Prado R, Azofra J, Fis I, Andía I.
Osteoarthritis and Cartilage. 2008;16(4):S44.
Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients.
Anitua E, Sánchez M, Nurden AT, Zalduendo MM, de la Fuente M, Azofra J, Andía I.
Rheumatology (Oxford). 2007 Dec;46(12):1769-72.
Reciprocal actions of platelet-secreted TGF-beta1 on the production of VEGF and HGF by human tendon cells.
Anitua E, Sánchez M, Nurden AT, Zalduendo M, de la Fuente M, Azofra J, Andia I.
Plast Reconstr Surg. 2007 Mar;119(3):950-9.
Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities.
Anitua E, Sánchez M, Nurden AT, Zalduendo M, de la Fuente M, Orive G, Azofra J, Andia I.
J Biomed Mater Res A. 2006 May;77(2):285-93.
Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture.
Anitua E, Andía I, Sánchez M, Azofra J, del Mar Zalduendo M, de la Fuente M, Nurden P, Nurden AT.
J Orthop Res. 2005 Mar;23(2):281-6.