The Arthroscopic Surgery Unit has over 70 publications in basic research, clinical research and scientific divulgation, to contribute to the development of medicine based on evidence in the realm of treatments using plasma in injuries to the musculoskeletal system.
The end goal of the research is to improve the quality of patients’ lives and divulge experience in the medical realm so that it can be contrasted and used by other medical professionals.
Current Challenges in the Development of Platelet-Rich Plasma-Based Therapies
Mercader Ruiz J, Beitia M, Delgado D, Sánchez P, Porras B, Gimeno I, González S, Benito-Lopez F, Basabe-Desmonts L, Sánchez M.
BioMed Research International Volume 2024, Article ID 6444120, 21 pages
Validation of a rapid collagenase activity detection technique based on fluorescent quenched gelatin with synovial fluid samples
de la Fuente, M., Delgado, D., Beitia, M. et al.
BMC Biotechnol 24, 50 (2024)
A Novel Fibrin Matrix Derived from Platelet-Rich Plasma: Protocol and Characterization.
Delgado D, Beitia M, Mercader Ruiz J, Sánchez P, Montoya-Alzola M, Fiz N, Sánchez M.
Int J Mol Sci. 2024 Apr 6;25(7):4069.
Method to obtain a plasma rich in platelet- and plasma-growth factors based on water evaporation
Mercader Ruiz J, Beitia M, Delgado D, Sánchez P, Sánchez MB, Oraa J, et al.
PLOS ONE 19(2): e0297001.
Method Based on Ultrafiltration to Obtain a Plasma Rich in Platelet and Plasma Growth Factors
Mercader Ruiz J, Beitia M, Delgado D, Sánchez P, Guadilla J, Pérez de Arrilucea C, Benito-Lopez F, Basabe-Desmonts L, Sánchez M.
J Clin Med. 2023 Sep 13;12(18):5941
New Formulation of Platelet-Rich Plasma Enriched in Platelet and Extraplatelet Biomolecules Using Hydrogels
Mercader Ruiz J, Beitia M, Delgado D, Sánchez P, Arnaiz MJ, López de Dicastillo L, Benito-Lopez F, Basabe-Desmonts L, Sánchez M.
Int J Mol Sci. 2023 Sep 7;24(18):13811
Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA Orthobiologic Initiative. Part 2: bone marrow-derived cell-based injectable therapies
Boffa A, Perucca Orfei C, Sourugeon Y, Laver L, Magalon J, Sánchez M, Tischer T, de Girolamo L, Filardo G.
Knee Surg Sports Traumatol Arthrosc. 2023
The Dual-Responsive Interaction of Particulated Hyaline Cartilage and Plasma Rich in Growth Factors (PRGF) in the Repair of Cartilage Defects: An In Vitro Study
Anitua E, Prado R, Guadilla J, Alkhraisat MH, Laiz P, Padilla S, García-Balletbó M, Cugat R.
Int J Mol Sci. 2023 Jul 18;24(14):11581
The effect of short-term cryopreservation on the properties and functionality of platelet-rich plasma
Beitia M, Delgado D, Mercader J, Gimeno I, Espregueira-Mendes J, Aizpurua B, Sánchez M.
Platelets, 34:1, DOI: 10.1080/09537104.2023.2210243
Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA Orthobiologic Initiative. Part 1: adipose tissue-derived cell-based injectable therapies
Perucca Orfei C, Boffa A, Sourugeon Y, Laver L, Magalon J, Sánchez M, Tischer T, Filardo G, de Girolamo L.
Knee Surg Sports Traumatol Arthrosc. 2022
Isolation of Platelet-Derived Exosomes from Human Platelet-Rich Plasma: Biochemical and Morphological Characterization
Saumell-Esnaola M, Delgado D, García Del Caño G, Beitia M, Sallés J, González-Burguera I, Sánchez P, López de Jesús M, Barrondo S, Sánchez M.
Int J Mol Sci. 2022 Mar 5;23(5):2861
Platelet-rich plasma injections induce disease-modifying effects in the treatment of osteoarthritis in animal models
Boffa A, Salerno M, Merli G, De Girolamo L, Laver L, Magalon J, Sánchez M, Tischer T, Filardo G.
Knee Surg Sports Traumatol Arthrosc. 2021
Platelet Lysate Nebulization Protocol for the Treatment of COVID-19
Beitia M, Delgado D, Sánchez P, Vallejo de la Cueva A, Cugat JR, Sánchez M.
Int J Mol Sci. 2021 Feb 12;22(4):1856.
Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age
Delgado D, Bilbao AM, Beitia M, Garate A, Sánchez P, González-Burguera I, Isasti A, López De Jesús M, Zuazo-Ibarra J, Montilla A, Domercq M, Capetillo-Zarate E, García Del Caño G, Sallés J, Matute C, Sánchez M.
Int J Mol Sci. 2021
Biological and structural effects after intraosseous infiltrations of age‐dependent platelet‐rich plasma: An in vivo study
Sánchez M, Delgado, D, Garate A, Sánchez P, Bilbao A, García del Caño G, Salles J
Journal of Orthopaedic Research Society, volume 38, Issue 9, Pages 1931-1941. September 2020
Autologous bioscaffolds based on different concentrations of platelet rich plasma and synovial fluid as a vehicle for mesenchymal stem cells
Garate A, Sánchez P, Delgado D, Bilbao AM, Muiños-López E, Granero-Moltó F, Orive G, Prosper F, Pedraz JL, Sánchez M
J Biomed Mater Res A. 2018 Feb;106(2):377-385.
Cryopreservation of Human Mesenchymal Stem Cells in an Allogeneic Bioscaffold based on Platelet Rich Plasma and Synovial Fluid
Gurruchaga H, Saenz del Burgo L, Garate A, Delgado D, Sánchez P, Orive G, Ciriza J, Sánchez M, Pedraz JL
Sci Rep. 2017; 7: 15733
Adult Cells Combined With Platelet-Rich Plasma for Tendon Healing: Cell Source Options
Rubio-Azpeitia E, Sánchez P, Delgado D, Andia I
Orthop J Sports Med. 2017 Feb 24;5(2):2325967117690846
Modulation of Synovial Fluid-Derived Mesenchymal Stem Cells by Intra-Articular and Intraosseous Platelet Rich Plasma Administration
Muiños-López E, Delgado D, Sánchez P, Paiva B, Anitua E, Fiz N, Aizpurua B, Guadilla J, Padilla S, Granero-Moltó F, Prósper F, Sánchez M
Stem Cells Int. 2016;2016:1247950.
The Properties of 3 Different Plasma Formulations and Their Effects on Tendinopathic Cells
Rubio-Azpeitia E, Bilbao AM, Sánchez P, Delgado D, Andia I.
American Journal of Sports Medicine
Three-Dimensional Platelet-Rich Plasma Hydrogel Model to Study Early Tendon Healing
Rubio-Azpeitia E, Sánchez P, Delgado D, Andia I.
Cells Tissues Organs. 2015 Nov 13;200(6):394-404.
Ultrasound-guided plasma rich in growth factors injections and scaffolds hasten motor nerve functional recovery in an ovine model of nerve crush injury
Sánchez M, Anitua E, Delgado D, Prado R, Sánchez P, Fiz N, Guadilla J, Azofra J, Pompei O, Orive G, Ortega M, Yoshioka T, Padilla S
J Tissue Eng Regen Med. 2015
Infiltration of plasma rich in growth factors enhances in vivo angiogenesis and improves reperfusion and tissue remodeling after severe hind limb ischemia
Anitua E, Pelacho B, Prado R, Aguirre JJ, Sánchez M, Padilla S, Aranguren XL, Abizanda G, Collantes M, Hernandez M, Perez-Ruiz A, Peñuelas I, Orive G, Prosper F
J Control Release. 2015 Mar 28;202:31-9.
Plasma rich in growth factors (PRGF-Endoret) stimulates tendon and synovial fibroblasts migration and improves the biological properties of hyaluronic acid.
Anitua E, Sánchez M, De la Fuente M, Zalduendo MM, Orive G.
Knee Surg Sports Traumatol Arthrosc. 2011 Oct 11.
Plasma rich in growth factors (PRGF-Endoret) stimulates proliferation and migration of primary keratocytes and conjunctival fibroblasts and inhibits and reverts TGF-beta1-Induced myodifferentiation.
Anitua E, Sánchez M, Merayo-Lloves J, De la Fuente M, Muruzabal F, Orive G.
Invest Ophthalmol Vis Sci. 2011 Aug 1;52(9):6066-73.
Fibroblastic response to treatment with different preparations rich in growth factors.
Anitua E, Sánchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, Andía I.
Cell Prolif. 2009 Apr;42(2):162-70.
Autologous PRGF in the ovine ACL-transected knee osteoarthritis model.
Sánchez M, Anitua E, Guadilla J, Prado R, Azofra J, Fis I, Andía I.
Osteoarthritis and Cartilage. 2008;16(4):S44.
Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients.
Anitua E, Sánchez M, Nurden AT, Zalduendo MM, de la Fuente M, Azofra J, Andía I.
Rheumatology (Oxford). 2007 Dec;46(12):1769-72.
Reciprocal actions of platelet-secreted TGF-beta1 on the production of VEGF and HGF by human tendon cells.
Anitua E, Sánchez M, Nurden AT, Zalduendo M, de la Fuente M, Azofra J, Andia I.
Plast Reconstr Surg. 2007 Mar;119(3):950-9.
Autologous fibrin matrices: a potential source of biological mediators that modulate tendon cell activities.
Anitua E, Sánchez M, Nurden AT, Zalduendo M, de la Fuente M, Orive G, Azofra J, Andia I.
J Biomed Mater Res A. 2006 May;77(2):285-93.
Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture.
Anitua E, Andía I, Sánchez M, Azofra J, del Mar Zalduendo M, de la Fuente M, Nurden P, Nurden AT.
J Orthop Res. 2005 Mar;23(2):281-6.